A Review on Orodispersible Film-based Novel Drug Delivery System

Abstract

Orally-dissolving films, sometimes called orodispersible films (ODF), are a type of oral solid dosage form that dissolves quickly in the mouth without chewing or drinking liquids. These innovative pharmaceutical formulations have attracted a great deal of attention due to their exceptional ability to improve patient compliance and convenience, especially in children, the elderly, and patients with dysphagia, who may have trouble swallowing conventional solid dosage forms. The main goal of orodispersible films is to provide a rapid and effective drug delivery through the oral mucosa. This method of administration has several advantages, such as increased bioavailability, rapid action, and low first-pass metabolism. Orodispersible films have shown effectiveness in the treatment of a wide variety of ailments including mouth ulcers, allergic diseases, cold and cough, sore throat, nausea and restlessness. In the field of pharmacological intervention, these thin, flexible films, designed to quickly disintegrate upon contact with saliva, offer a viable therapeutic strategy. Plasticizers, medicines and organoleptic chemicals are among the substances that are used during the manufacturing of the film. These elements are essential to the normal structure and effectiveness of the film. For example, plasticizers are compounds that are added to film materials to improve their flexibility and toughness. They function by reducing the tension between polymer chains, thereby increasing the film's elasticity and resistance to cracking or breaking. On the other hand, drugs are incorporated into the film structure to accomplish certain therapeutic goals. The purpose of this study is to provide an in-depth review on the fundamental concepts and processes that govern the formulation and evaluation of film, as well as examine the critical factors involved in the packaging process.