A Novel approach to develop Etodolac Emulgel with Alkaloidal Penetration Enhancer

Abstract

The aim of present study is to development of novel formulation present unique challenge. The topical route has long been used for delivering drugs directly to the affected target site through the skin. Current approaches in design and optimization of topical formulation necessitate extensive decisions in choosing the right components for the formulation to achieve high safety clinical efficacy and patient compliance it was concluded that etodolac emulgel formula could be very promising topical alternative for the conventional dosages from provide sustained and prolonged delivery of drugs. The results of this research establish a new and useful approach in designing the oil phase of a formulation where the active ingredient needs to be dissolved in the oil phase and develop emulgel system. Additionally, the use of emulgels for topical delivery of hydrophobic drugs has been found to be better at achieving a higher drug concentration over a longer period of time across the skin barrier as compared to gels.