Development and Validation of a New Stability Indicating Liquid Chromatographic Method for the Simultaneous quantification of Hydrochlorthiazide and Telmisartan-Reference-Cited by-同舟云学术

Development and Validation of a New Stability Indicating Liquid Chromatographic Method for the Simultaneous quantification of Hydrochlorthiazide and Telmisartan

Published:2021-04-29 Issue: Volume: Page:2081-2088
ISSN:0974-360X
Container-title:Research Journal of Pharmacy and Technology
language:en
Short-container-title:RJPT

Author:

Lingamaneni Kalyani¹,Mathrusri Annapurna Mukthinuthalapati¹

Affiliation:

1. Department of Pharmaceutical Analysis and Quality Assurance, Gandhi Institute of Technology and Management (Deemed to be University), GITAM Institute of Pharmacy, Visakhapatnam, Andhra pradesh-530045, India

Abstract

Telmisartan is an angiotensin receptor blocker and Hydrochlorothiazide is used to treat edema caused by various heart, kidney and liver diseases. Telmisartan is used in combination with a thiazide-type diuretic such as Hydrochlorothiazide by which an additive blood pressure lowering effect was proved. A new stability indicating liquid chromatographic method has been developed for the simultaneous estimation of Telmisartan and Hydrochlorthiazide in tablets. Chromatographic separation was achieved by using a X Bridge shield RP C-18 (150mm × 3.0mm, 3.5µm) column of Waters HPLC with Empower2 software and PDA detector, maintained at 45 ºC. Gradient mode of elution was performed and the flow rate of the mobile phase was 0.8 mL/min (Detector wavelength 235nm). Forced degradation studies were performed and the proposed method was found to be selective and specific.

Publisher

A and V Publications

Subject

Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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