Anti-oxidant and Anti-microbial activities of 2’’, 4’’-thiazolidindione derivatives of 7-flavonols

Abstract

Objective: The synthesized compounds of 2’’,4’’-thiazolidindione derivatives of 7-flavonols*, after characterization, aimed to be tested for their anti-oxidant and anti-microbial effects. Methods: i) Free radical scavenging actions tested by hydrogen peroxide- nitric oxide- and by alkaline DMSO- methods and ii) anti-microbial effects against various bacterial pathogens and against candida albicans by disc diffusion method. Results: Data were found to be dose dependent and IC50 value was 30-60 µg/ml and the results revealed that the dinitro-, trinitro- and acetyl, dinitro derivatives showed better and/or equipotent activity to that of the standard, ascorbic acid. The synthesized compounds exerted variable inhibitory activities at a concentration of 1μg /10μl /disc with inhibition zone ranging from 7-26 mm in diameter and a good antifungal activity against Candida albicans at the concentration of (1μg /10μl /disc) with inhibition of 10-24 mm. Klebsiella tribatta are more susceptible to the action of the formylated samples, giving high inhibition values comparing to the other organisms. Compounds Ie and Ih resulted to a higher activity index (AI>1); compounds Id, Ig and Ii showed an equal value (AI=1); whereas, Ia, Ib, Ic and If showed only a moderate activity (AI<1) compared to the standard, Amikacin. Conclusion: The findings confirmed that the synthetic compounds of 3-formyl, 7-flavonol derivatives have significant anti-oxidant and anti-microbial activities.