Antidiarrhoeal Potential of various Solvent Extracts of Achyranthes aspera against three diverse diarrhoeal animal models

Abstract

Diarrhoea is a condition characterized by a variation in the bowel movement. It is one of the major health issues in developing countries. Its severity is more in children’s. Diarrhoea causes severe dehydration and some time it may lead to death. Globally, over 5 million children’s are dying each year because of diarrhoea. In the present scenario, herbal medicines are used by the people in a wider range because of its safety as compared to synthetic drugs. So it is very crucial to identify and investigate available natural drugs for treating diarrhoea. Hence, the present study endeavor the evaluation of antidiarrhoeal activity of Achyranthus aspera. The anti-diarrhoeal activity was performed by using different animal models like castor oil-induced diarrhoea, prostaglandin-E2 induced enteropooling and gastrointestinal motility test. All the extracts of Achyranthus aspera showed considerable antidiarrhoeal activity in all the three animal models by reducing diarrhoeal episodes. The findings of the present investigation revealed the significant antidiarrhoeal property of Achyranthes aspera. Hence this plant can be used in the suitable form as an alternative to available synthetic antidiarrhoeal medicines which are not completely safe. Thus the adverse effects of synthetic drugs can be minimized by reducing its use.