Affiliation:
1. Chemistry Department,Faculty of Education for girl, University of Kufa, Najaf.
2. Pharmaceutical Department, Faculty of pharmacy,University of Kufa, Najaf.
Abstract
This paper involves synthesis new Mannich bases derived from Shiff' bases which prepared from isatin by the reaction of isatin with different aromatic amines to prepare Shiff bases derivatives (M, G, B, R, X, S), then Shiff's bases derivatives reacted with formaldehyde and piperazine to produce Mannich bases derivatives (M1, G1, B1, R1, X1, S1). The third step included the assay of biological activity of all compounds against four types of pathogens bacteria (Staphylococcus aureus, Granutice tella adiacens) gram positive and (E. coli, Proteus mirabilis) gram negative the results exhibited excellent biological activity for all derivatives compared to antibiotics (Ampicillin and Ciprofloxacin) these structures were identified by FT-IR,1HNMRand 13CNMR.
Subject
Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Reference25 articles.
1. Grewal, A.S. International Journal of Pharmaceutical Research, 2014; 6(1).
2. Khan, F.A. and Maalik A.,Trop J. Pharma. Res., 2015; 14(10).
3. Ibrahim S.A. and Esaman T., JPRI, 2018; 21(2):1-19.
4. Shalof R.T., Tawfik E.H. and Fadaa A.A. Chemical Silences Journal. 2018; 9(3):1-6.
5. Nassar, M.Y., Ahhmad I.S., Dessouki H.A. and Ali S.S., Journal of Basic and Environment Sciences, 2018; 5: 60-71.
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