Affiliation:
1. Department of Pharmaceutical Quality Assurance, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Tal. Bhor, Dist. Pune, Maharashtra.
Abstract
A new, simple, accurate, precise and reproducible UV-Spectrophotometric method is being developed for the simultaneous estimation of Metformin Hydrochloride and Voglibose in tablet dosage form. The stock solutions were prepared in methanol. The λmax for Metformin Hydrochloride and Voglibose were found to be248 nm and 287nm respectively. The Metformin Hydrochloride and Voglibose obeyed Beer’s law in concentration range of 8-16µg/ml and 4-20µg/ml respectively. Results of analysis of absorbance ratio method were analysed and validated for various parameters according to ICH guidelines for accuracy, precision, linearity, robustness, LOD and LOQ. The proposed method is highly sensitive, precise and accurate, therefore can be used for intended purpose.
Subject
Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Reference40 articles.
1. T. K. Ravi. Development and validation of UV- Spectroscopic method for estimation of Voglibose in bulk and tablets. J Chem Pharm Res. 2010; 2(2): 350-356.
2. G. Mubeen, K. Noor. Spectrophotometric Method for Analysis of Metformin Hydrochloride. Ind J Pharm Sci. 2009; 71 (1): 100-102.
3. Y. D. Dange et.al. Development and Validation of UV-Spectrophotometric Method for Estimation of Metformin in Bulk and Tablet Dosage Form. Ind J Pharma Edu Res.2017; 51 (4): 5784-5790.
4. A. Parle. Development and validation of UV spectrophotometric method for simultaneous estimation of metformin hydrochloride and Alogliptin benzoate in bulk drugs and combined dosage forms. Der Pharma Chemica, 2014; 6(1): 303-311.
5. R. Karim et.al Development and validation of UV spectroscopic method for the determination of metformin hydrochloride in tablet dosage form. IJPSR 2012; 3(9): 3170-3174.
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献