Nanosuspension as an emerging Nanotechnology and Techniques for its Development

Abstract

Low bioavailability is one of the major concerns associated with drugs which show poor aqueous solubility. The problem is even more complex for drugs belonging to BCS class II as classified by BCS classification system, showing poor solubility in both aqueous and nonaqueous media such as drugs like carbamazepine, itraconazole etc. Nanosuspension, a novel technology has shown its potential to be a promising alternative to solve these problems concerning solubility. A nanosuspension is a formulation of the poorly water-soluble drug without any matrix material suspended in dispersion. It is a simple technique and applicable to all drugs which are water insoluble. Apart from improving solubility and bioavailability, nanosuspension also alters the pharmacokinetics of drug and of the nanosuspension.