Anti-Post-Traumatic stress Potential of Strawberry (Fragaria) and Carissa carandas Leaves: A Review

Abstract

Post-traumatic stress disorder (PTSD) is the least apperceived mental disorder globally, associated with trauma and stressor cognate disorder. Administration of synthetic drugs on a constant schedule may lead to adverse events and other complications. Thus, Anti-PTSD medications require novel herbal pharmacological therapy. Recently, Anti-PTSD activity of Carissa carandas (CC) and Fragaria leaves (FL) has been demonstrated. Both are valuable bioresource for a range of health-related applications since they accommodate as a source of bioactive compounds with powerful antioxidant potential higher than in other berries. They possess faculty to cross the blood-brain barrier and chelate transition metal ions as well as forage pathological amounts of reactive oxygen and nitrogen species. For neuro-pathophysiology and pharmacological evaluations, pharmacologically different animal models of PTSD have been developed. Animal models are a prominent approach to learn PTSD without requiring to use of actual victims. A genuine effort has been taken in this article which provides the clear and cosine worldwide proven anti-PTSD potential of CC and Fl. The objective behind this article is to new vision to present and future scientists, researchers, industries, and regulatory bodies on the potential anti-PTSD potential of CC and Fl for the betterment of society by highlighting clinical and pre-clinical studies which contributed to support the concept. Any outcome in a model can be extrapolated to humans, giving scientists a better picture of what to anticipate mechanistically and in treatment response. Thus, CC and FL have wide application in mental disorders precisely in PTSD and as being herbal formulation, it has lesser adverse effects as compared to synthetic drugs.