Preparation of Apamarg Kshar Tablet and Assessment of In Vitro Potential against Urolithiasis (Mutrakrichra)

Author:

Singh Baghel Dileep1,Singh Saurabh1,Kumar Pandey Narendra1,Kumar Bimlesh1,Mittal Amit1,Kumar Chaudhary Anand2,Mittal Anu3,Singh Amrik4

Affiliation:

1. School of Pharmaceutical Sciences, Lovely Professional University, Punjab, India.

2. Department of Rasa Shastra and Bhaishjya Kalpana (Ayurvedic Pharmaceutics), Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India.

3. Department of Chemistry, Guru Nanak Dev University Collage, Patti, Tran Taran, Punjab, India.

4. School of Hotel Management and Tourism, Lovely Professional University, Punjab, India.

Abstract

Background: Urolithiasis (Mutrakricchra) is an age-old disorder which has multi-factorial etiological as well as associated with re-occurrence. It is standout among the most troubling disorders related to urinary tract. Acharya Sushruta, a pioneer in the art of surgery, described the root causes and management of urolithiasis (Mutrakricchra). In present day restorative practice, a lot of the management/treatment choices are available which begins from the utilization of uresis-elevating specialist to dietary or nourishing enhancement consumption. Amalgamating the Ayurvedic principle/concept with current medicinal practice is a promising methodology used for the management of urolithiasis (Mutrakricchra) now a days. Objective: To prepare apamarg kshar and evaluate its potential against Urolithiasis (Mutrakrichra) by In-vitro technique. Materials and Methods: Apamarg kshar were prepared as per the methodology mentioned in Rasatarangni and the prepared Kshar is compressed in tablet dosage form. Various parameters of apmarg kshar tablets were evaluated. Results: Physicochemical and stability studies have not shown any remarkable variations with prepared tablet dosage form. In-vitro studies shows that 82 % of crystal inhibition at 550 µg/ml. Conclusion: The prepared tablet dosage form of Apamarg Kshar does not have remarkable variation during physicochemical and stability studies. The developed dosage form produces promising result in vitro against Urolithiasis (Mutrakrichra).

Publisher

A and V Publications

Subject

Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Reference40 articles.

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2. Sastri, K., Charak Samhita by Agnivesa. Chaukhambha Bharti Academy, Varansi, 2013.

3. Yadavji, A.T., Sushruta Samhita by Sushruta. Krishnada Academy, Varanasi, 1980.

4. Shanmugapriya, J. and S. Kumar, A prospective study on quality of life in patients with urinary calculi. Asian Journal of Pharmaceutical and Clinical Research, 2017: p. 191-193.

5. Chunekar, K.C. and G. Pandey, Bhavprakash nighantu. Chukhamba bharti academy, Varanasi, 2004.

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