Relation between Vit. D3 and other Metabolic Risk Factors in patients with Cholestatic Liver Disease

Abstract

Cholestasis defined as distortion of bile duct formation or outflow. hepatic cytotoxicity, fibrosis and biliary sclerosis are the main complications of liver disease. Recently found that significant relationship between cholestasis and vitamin D3 therefore many studies demonstrate that vit.D3 deficiencies may develop to osteomalacia especially in bile duct obstruction. The results were included different parameters like (ALT, AST, ALK.P, TSB and Vit.D3)., also different distributions of patients for examples hypertension, dyslipidaemia, myocardial Infraction and smoking, the results appeared increased significant value (p<0.05) of weight, systolic and diastolic except height, there was decreased level while no significant (p>0.05) of Age in patients as compared with control groups also there was increased significant value (p<0.05) in each of Alanine Transferase (ALT), Alkaline Phosphatase (ALK.P), Total Serum Bilirubin (TSB) except Vit.D3 there was decreased level while no significant (p>0.05) of Aspartate Transferase (AST) in patients as compared with control groups. Receiver operator curve (ROC) analysis of ALK.P and Vit.D3 is determined acceptable values of sensitivity and specificity. Also boxplot graphs expressed by Statistical Packages for Social Sciences-version used to compare between patients and healthy subjects.