A Facile Synthesis of Octadecanoic acid [4-(3-phenyl-acryloyl)-phenyl]-amides and their Antimicrobial Activity

Abstract

A new series of octadecanoic acid [4-(3-phenyl-acryloyl)-phenyl]-amide chalcone derivatives under base-catalyzed Claisen-Schmidt condensation were design, synthesized and characterized by spectral analysis (IR, MS, 1H-NMR, 13C-NMR). All the synthesized compounds were evaluated for their in vitro antimicrobial activity against two bacterial strains, Escherichia coli and Staphylococcus aureus and two fungal strains, Penicillium italicum and Fusarium oxysporum using the well-diffusion method. The antimicrobial studies revealed that compounds 3a, 3b, 3c and 3d showed promising antibacterial activity against both the bacterial strains, while compound 3c and 3d exhibited good antifungal activity against both the fungal strains.