Affiliation:
1. Professor, Oral Medicine and Radiology, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha.
Abstract
Areca nut (AN) is the fourth most widely used addictive substance and chewed regularly by at least 10% of the world population. AN cause many harmful effects on the human body in general as well as in the oral cavity. Amongst this one of the vital organs being damaged due to AN consumption is liver for which a number of mechanisms are reported to be responsible. Frequently alkaloids in AN are considered as the main culprit. But, other components like copper (Cu) content in AN is also believed to play a role in the pathogenesis of liver fibrosis. It is stated that an adult Indian chewing AN daily consumes over 5 mg of Cu per day, of which the substantial amount is absorbed. However, the recommended intake per day is 0.9 mg. Excess Cu acts by upregulating lysyl oxidase activity, which enhances collagen synthesis and inhibits collagen degradation leading to fibrosis of tissues. Another reason for liver toxicity could be reactive oxygen species generated by Cu content in AN. Thus, it may be stated that Cu in AN can be one of the risk factors inducing liver damage. The present review highlights the role of Cu content of AN in the development of liver fibrosis.
Subject
Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Reference52 articles.
1. Patel PK, Prajapati NK, Dubey BK. Hepatotoxicity: Causes, Symptoms and Herbal Remedies. Research J. Pharmacognosy and Phytochemistry 2012; 4(2): 104-111.
2. Nur Qistina Binti Ahmad Fauzi, Vishnupriya V, Gayathri R. Fatty Liver Disease - A Review. Research J. Pharm. and Tech 2016; 9(8):1263-1267.
3. Choudhari S, Jothipriya A. Non-Alcoholic Fatty Liver Disease. Research J. Pharm. and Tech 2016; 9(10):1782-1785.
4. Affrin JH., Savitha. G. Serum gamma glutamyl transferase activity in liver diseases. Research J. Pharm. and Tech. 2018; 11(1): 387-389.
5. Simon V, Sreerag KV, Sasikumar R, Kanthlal SK. High dose antibiotics induced hepatotoxicity and altered markers: An in-vitro liver slices study. Research J Pharm and Tech. 2017; 10(6): 1742-1745.
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