Affiliation:
1. College of Remote Sensing and Geophysics, Al Karkh University of Science, Baghdad, Iraq.
Abstract
This study describes the synthesis of new Schiff base ligand (L') derived from isatin with 2- amino-6-methylbenzothaizole, also prepared mixed ligand complexes from curcumin (HL) and Schiff base (L') with metal ions, give formula: [M(L)(L') Cl] where: M = [Mn, Co, Ni, Cu, Zn, Cd], With (M: HL: L') [1:1:1] in ethanol as a solvent. The Schiff base (L') and all complexes were characterized by spectroscopic measurements (IR, 1H,13C-NMR, UV-Vis, A.A., LC-mas), magnetic susceptibility, elemental microanalysis, molar conductivity, chloride content, and melting point. Based on the results obtained an octahedral geometrical formula was suggested for all prepared complexes. The evolution of biological activity for ligands and their complexes was valued for two kinds of bacteria: (Escherichia coli, Staphylococcus aureus) and only one type for each of the mildew Candida Albicans. The results showed that the biological activity of the complexes against the bacteria and mildew are best than the ligands.
Subject
Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
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