In vivo Antidiabetic properties of Etlingera elatior Leaf Extract in Alloxan-Induced Diabetic Rats-Reference-Cited by-同舟云学术

In vivo Antidiabetic properties of Etlingera elatior Leaf Extract in Alloxan-Induced Diabetic Rats

Published:2022-09-28 Issue: Volume: Page:3879-3886
ISSN:0974-360X
Container-title:Research Journal of Pharmacy and Technology
language:en
Short-container-title:RJPT

Author:

Rahma Turista Dora Dayu¹,A’yunin Lathifah Qurrotu²,Muhammad Ansori Arif Nur³,Antonius Yulanda⁴,Villar Posa Gabrielle Ann⁵,Choirur Rizky Wahyu⁶,Antonius Dings Tim Godefridus⁷,Kazhibayeva Galiya⁸,Omarova Karina⁸,Anikina Irina⁸

Affiliation:

1. Biology Education Department, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, Indonesia.

2. Department of Medical Laboratory Technology, STIKES Hutama Abdi Husada, Tulungagung, Indonesia.

3. Professor Nidom Foundation, Surabaya, Indonesia.

4. Faculty of Biotechnology, University of Surabaya, Surabaya, Indonesia.

5. School of Environmental Science and Management, University of the Philippines Los Baños, Los Baños, Philippines.

6. College of Medicine, Sulaiman Al Rajhi University, Al Bukayriyah, Qassim, Saudi Arabia.

7. College of Medicine, Maastricht University, Maastricht, The Netherlands.

8. Department of Biotechnology, Toraighyrov University, Pavlodar, Kazakhstan.

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Application of alloxan in experimental animals can cause Diabetes mellitus. The secondary metabolites of Etlingera elatior can be used as raw materials for diabetes mellitus drug. This study aims to determine the antidiabetic potential of ethanol extract of Etlingera elatior leaves by in vivo study. A total of 32 rats were divided into 6 groups, namely NC, DC, PC, DE1, DE2, and DE3. The results of data analysis using multivariate ANOVA on blood glucose level data every week showed p(0.000) < (0.05), and the results of data analysis using one way ANOVA on pancreatic β cell count data also showed that p(0.000) < (0.05). Etlingera elatior leaf ethanol extract has antidiabetic activity since it could reduce blood glucose levels and increase the number of pancreatic β beta cells through several mechanisms. The mechanism is triggered by phytochemical compounds contained in the leaf extract of Etlingera elatior.

Publisher

A and V Publications

Subject

Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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