Correlation between Interleukin-6, CRP, and LDH in COVID-19 patients of Dr. Soetomo Teaching Hospital, Surabaya, Indonesia

Abstract

This cross-sectional study was conducted from June 2020 to May 2021. This study recruited 86 patients with confirmed PCR positive for COVID-19 who were treated in the isolation ward of Dr. Soetomo Teaching Hospital, Surabaya, Indonesia. Examination of serum levels of IL-6, CRP, and LDH was performed on the first and the sixth day of hospital admission. Found on the first day of admission the same significant correlation between IL-6 and CRP on males and females with rs=0,475 (p<0,01) and rs=0,663 (p<0,01) respectively. Correlation between IL-6 and LDH on the first day of admission on both males and females were also significant with rs=0,403 (p<0,01) and rs=0,484 (p<0,01) respectively. IL-6 and CRP on the sixth day of admission showed significant correlation on males with rs=0,621 (p<0,01), but not on females with rs=0,120 (p=0,586). IL-6 and LDH on the sixth day of admission also showed significant correlation on males with rs=0,544 (p<0,01), but not on females with rs=0,030 (p=0,893). In conclusion, there were significant positive correlations between IL-6, CRP, and LDH on the first day of admission on both male and female subjects which showed that IL-6 was associated with inflammatory response on the acute phase of COVID-19. However, on the sixth day of admission, IL-6 showed significant positive correlations with CRP and LDH only on male subjects, but not on female subjects.