Chemically synthesized Schiffs base Conjugated Piperonal as novel Antioxidants and Scavengers of Free Radicals

Author:

Prakash Karurkar Ashwin1,Venkatraman Anuradha1,Mohammed Yacoob Syed Ali2,Ahmed Asrar3,Sihabudeen Mohamed3

Affiliation:

1. PG and Research Department of Biochemistry, Mohamed Sathak College of Arts and Science, Sholinganallur, Chennai-119.

2. PG and Research Department of Biotechnology, Mohamed Sathak College of Arts and Science, Sholinganallur, Chennai-119.

3. PG & Research Department of Chemistry, Jamal Mohamed College, Trichy-620020.

Abstract

Ethylene diamine is an organic compound which is a strongly basic amine and is used to conjugate Piperonal, an heterocyclic aldehyde. The ethylene diamine conjugated piperonal was prepared using simple method and the antioxidant assays like DPPH, ABTS, Ferric reducing assay and several other methods were carried out through in vitro assays. The experiments were carried out with unconjugated piperonal and compared with the activity shown by the test sample. The overall result shows a good antioxidant effect when compared with various standard drugs such as ascorbic acid, gallic acid, BHT etc., Hence, the results proved that, conjugated piperonal can be used as antioxidants in scavenging free radicals generated as consequence of various disease condition. Further, the synthesised compound can be explored for various experimental studies to confirm their role in combating various diseases.

Publisher

A and V Publications

Subject

Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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