Development of the composition and research of soft dosage forms with carbon dioxide extract from Scabiosa ochroleuca L.

Abstract

The article presents the research results on the development of dosage forms with carbon dioxide extract from pale yellow scabious (Scabiosa ochroleuca L.) for topical use. The lipophilic and hydrophilic ointments bases under the conditional name "Scabiol" were taken as objects of research. Rheological studies were carried out using a rotary viscometer of the "Reotest-2" type (Germany) using a cell consisting of systems of coaxial cylinders (S/S1). The speed of rotation of the inner cylinder was regulated by changing the gap between the cylinders, as well as the speed of rotation, and the tangential shear stress was determined. The study of the structural and mechanical properties of the "Scabiol" ointments was carried out at temperatures of 25, 40 and 55 oC. The shear stress and dynamic viscosity of the ointments were measured. Based on the obtained results, graphs were constructed that characterize the changes in the logarithm of the effective viscosity from the gradient of the shear flow rate, and the dependence of the gradient of the shear flow rate on the shear stress. The results of rheological studies showed the absence of structural changes in the shear field with the destruction or appearance of new compounds; the thixotropic properties of lipophilic and hydrophilic «Scabiol» ointments bases were also established. As a result of the study of the antimicrobial and antifungal activity of dosage forms with carbon dioxide extract of pale yellow scabious, it was found that to some extent, ointments inhibit the growth of test cultures in vitro. High-intensity antimicrobial activity was shown by lipophilic ointment "Scabiol" against Staphylococcus aureus, and Escherichia coli.