Chemical Composition and Antiproliferative and Antioxidant Activities of Essential Oil from Juniperus phoenicea L. Cupressaceae

Author:

Bajes Hana R.1,Oran Sawsan A.2,Bustanji Yasser K.3

Affiliation:

1. Department of Biological Sciences, The University of Jordan, Amman, Jordan.

2. School of Pharmacy, The University of Jordan, Amman, Jordan.

3. Hamdi Mango Center for Academic Research, The University of Jordan, Amman, Jordan.

Abstract

Being multipurpose, relatively safe, and widely favorable for consumption, interest in the essential oils of medicinal plants has been increasing. Essential oil (EO) of Juniperus phoenicea is traditionally used for treatment of several health problems such as diabetes, rheumatism, and cancer that is the second leading cause of death in Jordan. This study aims to collect and chemically analyze EO from Juniperus phoenicea L., from Jordan and to evaluate its cytotoxic and antioxidant activity against human breast cancer cells (T47D), colorectal adenocarcinoma cells (CACO2), and normal human fibroblasts (MRC5). EO was extracted by hydro-distillation and analyzed in a gas chromatograph coupled with a mass spectrometer. Cell viability was assessed using trypan blue, neutral red, and MTT assays, and antioxidant activity was evaluated using DPPH scavenging activity assay. Chemical composition analysis revealed 23 constituents in the EO, and the amount of α- pinene was the highest (69.71%). The results also revealed that the IC50 values of the viability assays were higher among normal cells compared to the human cancer cell lines, and the viability inhibition was significant at higher concentrations compared to untreated cells. Nevertheless, low antioxidant activity was observed for the oil in the DPPH scavenging activity test. To sum up, this study indicates that Jordanian Juniperus phoenicea EO, albeit unlikely to be an effective antioxidant, is optimistically potential to be utilized in breast and colon cancers treatment due to its preferential cytotoxicity against cancer cells.

Publisher

A and V Publications

Subject

Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Reference58 articles.

1. Al-Eisawi D, Flora of Jordan Checklist Revised. The University of Jordan Press. Amman, 2013: 149-187.

2. Oran SA, The status of medicinal plants in Jordan. Journal Agriculture, Science and Technology, 2014; A4(6A): 461-467.

3. Oran S and Al-Eisawi D, Check-list of medicinal plants in Jordan. Dirasat, 1998; 25(2): 84-112.

4. Oran SA and Al-Eisawi D, Ethnobotanical survey of the medicinal plants in the central mountains (North-South) in Jordan. Journal of Biodiversity and Environmnetal Sciences, 2015; 6(3): 381-400.

5. Oran SA, Selected wild plant species with exotic flowers from Jordan. International Journal of Biodiversity Conservation, 2015; 7(5): 308-320.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3