Synthesis of Novel 6-(chloromethyl) - N2- (1 - (4-substituted phenyl) - 3-phenyl - 1H-pyrazol - 4-yl) methylene)-N4- aryl-1, 3, 5-triazine - 2, 4-diamine derivatives and their Antimicrobial Activity-Reference-Cited by-同舟云学术

Synthesis of Novel 6-(chloromethyl) - N2- (1 - (4-substituted phenyl) - 3-phenyl - 1H-pyrazol - 4-yl) methylene)-N4- aryl-1, 3, 5-triazine - 2, 4-diamine derivatives and their Antimicrobial Activity

Published:2022-01-25 Issue: Volume: Page:236-244
ISSN:0974-360X
Container-title:Research Journal of Pharmacy and Technology
language:en
Short-container-title:RJPT

Author:

Kushwaha Neelottama¹,Sharma C.S.²

Affiliation:

1. Department of Pharmacy, Pranveer Singh Institute of Technology, Kanpur-209305, UP., India.

2. Associate Professor, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bhupal Nobles’ University, Udaipur, Rajasthan-313001, India.

Abstract

A series of 6-(chloromethyl)-N2-(1-(4-substituted phenyl)-3-phenyl-1H-pyrazol-4-yl) methylene)-N4-aryl-1, 3, 5-triazine - 2, 4-diamine 7(Aa-Gd) were synthesized using the appropriate synthetic procedure and characterized by spectral analysis. All the synthesized compounds were evaluated for their antibacterial and antifungal activities. The antibacterial activity was evaluated against Gram-positive strains (Staphylococcus aureus, Streptococcus aureus) and Gram-negative strains (Escherichia coli, Pseudomonas aeruginosa) using benzyl penicillin and streptomycin as standard drugs. Further, these compounds were studied for antifungal activity against three strains of fungi (Candida albicans, Aspergillus fumigate and Aspergillus flavus) using Ketoconazole as a standard drug. In the presented study all the synthesized compounds showed significant antibacterial and antifungal activities.

Publisher

A and V Publications

Subject

Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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