Evaluation of Antidepressant activity of Tricholepis glaberrima DC using various Paradigms

Author:

Jodh Rahul1,Tawar Mukund2,Kachewar Aparna1

Affiliation:

1. Department of Pharmacology, P.R. Pote Patil College of Pharmacy, Amravati – 444604.

2. Department of Pharmaceutics, P.R. Pote Patil College of Pharmacy, Amravati – 444604.

Abstract

In the present experiment, Tricholepis glaberrima DC has been taken to study its antidepressant activity. The study was carried out in two different doses of the test drug. The animals were divided into 4 groups of 5 animals each, respectively. Mice in Group I (control) and II (standard) were administered distilled water, per oral and Imipramine 10mg/kg, per oral once respectively. Group III and IV were treated with the test drug METG in the dose of 100mg/kg and 300mg/kg, respectively. Findings of the test groups were compared with that of standard as well as plain control groups. In despair swim test and Tail suspension method, METG (100mg/kg and 300mg/kg per oral) depicted significant (*p<0.05 and p<0.01) results, in a dose dependent manner, when compared to vehicle treated group, indicating significant antidepressant activity. The results obtained in the present study for antioxidant activity indicate that the plants of Tricholepis glaberrima DC are a significant source of natural antioxidants. This test reveals the antidepressant activity of Tricholepis glaberrima DC Via serotonergic, adrenergic mechanism in a dose dependent pattern.

Publisher

A and V Publications

Subject

Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Reference29 articles.

1. Annual booklet on Depression”, National Institutes of mental Health, U.S.A, department of health & human services, National Institutes of Health NIH Publication No. 11-3561Revised 2011.

2. American Psychiatric Association. American Psychiatric Association Practice Guidelines for the treatment of psychiatric disorders: compendium 2006. American Psychiatric Pub; 2006.

3. Berrios GE. Melancholia and depression during the 19th century: a conceptual history. The British Journal of Psychiatry. 1988 Sep;153(3):298-304. DOI: 10.1192/bjp.153.3.298

4. Venkatesh G, Kalaiyarasi C, Ramanathan M. Antidepressant like Effect of Gabapentin Decreases the Immobility Time in Despair Animal Models in Mice: Roll of Serotonergic System in it. Research Journal of Pharmacy and Technology. 2011; 4(11):1702-6.

5. Jabir FA, Hamzah SK. Evaluation of Anti-Depressant Activity of Petroleum Ether Extract of Rosa centifolia in Swiss Albino Mice. Research Journal of Pharmacy and Technology. 2018 May 30;11(5):2000-5. 10.5958/0974-360X.2020.00291.7

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