In-vitro Antifungal Evaluation of Some Cu and Ni Complexes

Abstract

The interaction of Copper and Nickel chloride with oximes of 2-Acetylfuran, 2-Acetylthiophene and 2-Acetylpyridine in absence of an external base resulted in formation of the complexes of the type [MCl2L2] (A) and [MCl2L2].H2O (A.H2O) {Here M: Cu or Ni; L: HON=C(CH3) Ar; where Ar = C4H3S, C4H3O or C5H4N}. The parent ligands were synthesized by green method using water as a solvent. Complexes were characterized by elemental analysis, 1H-NMR, IR spectral studies and these spectra were compared with that of free ligands. Spectral measurements suggest an octahedral or distorted octahedral geometry for all these complexes. The in-vitro Antifungal activity of all these complexes has proven that they are active against Candida albicans even at lower concentrations.