Synthesis, Characterisation, Anti-Cancer Activity and Docking Studies of 4-(4-(dimethylamino) phenyl)-1,3,6-triphenylpiperidin-2-one-Reference-Cited by-同舟云学术

Synthesis, Characterisation, Anti-Cancer Activity and Docking Studies of 4-(4-(dimethylamino) phenyl)-1,3,6-triphenylpiperidin-2-one

Published:2022-06-28 Issue: Volume: Page:2483-2485
ISSN:0974-360X
Container-title:Research Journal of Pharmacy and Technology
language:en
Short-container-title:RJPT

Author:

S Sumathi¹,Christopher Kanakam Charles²,B. Thanuja³

Affiliation:

1. Research and Development Centre, Bharathiar University, Coimbatore, Tamilnadu, India.

2. Department of Chemistry, Valliammai Engineering College, Kattankulathur, Tamilnadu, India.

3. Sri Sairam Engineering College, Chennai, Tamilnadu, India.

Abstract

The newly synthesised ligand 4-(4-(dimethylamino)phenyl)-1,3,6-triphenylpiperidin-2-one [DMP] with phenyl united piperidine moieties within the main cyclic chain was synthesized through the Michael addition reaction and qualitative analysis was characterised by FT-IR, NMR (13C, 1H). The present work deals with the computational analysis of a synthetic compound as a ligand with anticancer activity. The molecule is analysed for its druggable property and biological significance using several softwares. The molecule was docked with the receptor protein bearing the PDB ID 1UNG. The results of the anti-cancer of synthesised ligand DMP are correlated with the docking calculations performed on protein Cyclin-dependent kinase 5 using ligand fit protocol available through Acclerys Discovery studio 2.1

Publisher

A and V Publications

Subject

Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Reference21 articles.

1. Wang Y. Yuan YQ. Guo SR. Silica Sulfuric Acid Promotes Aza-Michael Addition Reactions under Solvent-Free Condition as a Heterogeneous and Reusable Catalyst. Molecules 2009; 14: 4779-4789.

2. Pitchai P. Sathiyaseelan M. Nepolraj A. Gengan RM. An elegant synthesis of indoloquinoline alkaloid cryptotackieine via Vilsmeier-Haack approach. Indian J. Chem. 2015; 54: 1290-1292.

3. Ram Janam Singh. Dharmendra Kumar Singh. Syntheses, Characterization and Biological Screening of Some Novel 1, 2, 4-Triazoles. Asian J. Research Chem. 2009; 2(4): 536-538.

4. Malmström J. Viklund J. Slivo C. Costa A. Maudet M et al. Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)-thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors. Bioorg. Med. Chem. Lett.2012; 18: 5919-23.

5. Testa B. Crivori P. Reist M. Carrupt PA. The influence of lipophilicity on the pharmacokinetic behavior of drugs: Concepts and examples. Perspect Drug Discov Des. 2000; 19: 179–211.