Evaluation of the effect of Simvastatin Therapy on Bone remodeling in Rats-Reference-Cited by-同舟云学术

Evaluation of the effect of Simvastatin Therapy on Bone remodeling in Rats

Published:2022-02-26 Issue: Volume: Page:525-528
ISSN:0974-360X
Container-title:Research Journal of Pharmacy and Technology
language:en
Short-container-title:RJPT

Author:

Ali Sami¹,Makhous Rana²

Affiliation:

1. Master Student, Department of Pharmacology and Toxicology, Tishreen University, Latakia, Syria

2. Professor, Department of Pharmacology and Toxicology, Tishreen University, Latakia, Syria

Abstract

Objective: The aim of this study was to evaluate the effect of simvastatin on the bone remolding markers in rats (experimental study). Materials and methods: The study involved 18 male Wistar rats, they were divided into three groups: Group I (n=6; control group), Group II (n=6; was administrated 7.5 mg/kg/ dexamethasone intra muscular for 2 months served as a model of osteoporosis [op]), Group III (n=6;was administered 7.5 mg/kg/ dexamethasone intra muscular for 2month and treated orally with 8mg/kg of simvastatin).After 8 weeks, serum acid phosphatase was determined for the three group. Results: The levels of serum acid phosphatase were notably elevated in the [op] group. Administration of simvastatin produced a significant decrease in the levels of serum acid phosphatase. Conclusion: simvastatin was able to decrease the rate of bone resorption in an animal model of osteoporosis induced by dexamethasone.

Publisher

A and V Publications

Subject

Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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