Formulation Characterization Optimization of Duloxetine loaded Ethosome Patch for Transdermal Application

Abstract

The present investigation deals with the development of duloxetine ethosome then loading into transdermal patch to impart lower drug side effect, enhanced bioavailability, avoid first pass metabolismt.32 factorial design was applied to optimize the formulation. Materials and Methods, Ethanol (X1) and Phospholipid (X2) were taken as independent variable, Responses are vesicle size (Y2), entrapment efficiency (Y1). Optimum desirability was identified and, an optimized formulation was prepared, characterized and loaded into transdermal films. Ex-vivo permeation study for the prepared films was conducted and, the permeation parameters and drug permeation mechanism were identified. Results The percent of alcohol was significantly affecting all the studied responses while the other factors and their interaction effects were varied on their effects on each response. The optimized ethosomes formulation showed observed values for Y2, Y1 a of 161nm and 98.79% respectively. Ex-vivo permeation of films loaded with optimized ethosomal formulation was superior to that of the corresponding pure drug transdermal films.