Evaluation of Anti-inflammatory Activity of Novel HDAC Inhibitors using in vitro Methods

Abstract

Inflammation is a neighborhood reaction to cell injury that is set apart by fine enlargement, leukocytic invasion, redness, heat, agony, expanding and loss of function. HDAC inhibitors play crucial role in regulation of inflammatory gene expression. The point of the investigation was to assess the anti-inflammatory activity of novel HDAC inhibitors having cinnamyl moiety. In the present study, two cinnamyl sulfonamide hydroxamate (CSH) derivatives (4a and 4b) were evaluated for their anti-inflammatory activity by in vitro methods, includes COX, LOX inhibitory assay, iNOS, MPO and determination of cellular nitrite level. The present study revealed that the newly derived compound 4a have potential anti-inflammatory activity and can serves as lead molecule in drug discovery.