Assessment of some Biochemical Parameters among Pleural Liquid and Serum during Platinum-based Chemotherapy against Ovarian Cancer

Abstract

Ovarian cancer (OC) is one of the main causes of cancer deaths in women. Owing to the retrieval effects of platinum-based chemotherapy in ovarian cancer patients, our aim is to study the effects of the first round of chemotherapy among women with ovarian cancer. Here, we have tested the levels of the pleural markers for the lipid profile and the bio markers of cancer, before and after the cis-platin based chemotherapy among ovarian cancer patients. The biochemical indicators may be used in deciphere the relevance between cancer retrogression and platinum recuperation. The pleural analyses before and after platinum chemotherapy session demonstrate wide range of alterations in the biochemical and protein markers among ovarian cancer patients. However, the pleural thickness and the pleural levels of the cancer biomarkers were not impressively reduced post chemotherapy. Hence, our data can be considered as a pavement for the discovery of further markers in the pleural liquid as well as a reliable monitor for chemotherapeutic response.