Reverse Pharmacology: An Innovative Approach to the Study of Herbs

Abstract

Despite significant advances in high throughput assays, the current state of drug discovery and development is facing an insurmountable challenge. For this reason, new methods for drug research are urgently needed. Ayurveda was used by almost 70% of Indians. The systematic and research-based search and investigation of native plants for beneficial and therapeutic effects should be modified. For this clarification, new scenarios and approaches were developed and developed Ayurvedic epidemiology, observational studies, and reverse pharmacological methods have produced remarkable achievements, indications, and components for a wide variety of diseases and conditions. The potential phytobase entity will appear in future scaffolds for medicinal chemists to increase potency while reducing toxicity. Many native medicinal herbs have been shown to be effective. Mucuna pruriens eggs are effective in treating Parkinson's disease, the Nycthanthes plant arbor-tritis is effective in treating malaria, and Phyllanthus amarus is used in treating hepatitis. Reverse pharmacology is used by several groups around the world for drug development of new formulations, chemicals, and baits.