Formulation, Development and Release Enhancement of Sustained Release Tablet of Antidiabetic Drug Glipizide by the use of Natural Polymers

Abstract

Background: Modification in sustained release system is a newly developed area that has shown good control over the administration of drug by maintaining systemic concentrations. Objective: The study was conducted to formulate a sustained release tablet of antidiabetic drug, glipizide, with improvement in patient’s compliance. Methods: Sustained release tablet of glipizide was prepared by using different concentration of natural polymers like guar gum, chitosan and xanthan gum as a release modifier by wet granulation method. The tablets had been analyzed by chemical and physical parameters. Drug and polymer interactions had been studied by FT-IR and in vitro drug release had been studied using rotating paddle dissolution apparatus. The release rate had been studied on different models in order to measure their release kinetics. Results: Obtained FT-IR spectra interpreted no interaction of used natural polymers. Over a period of 12 hrs the maximum drug release was 98.66%. Conclusion: The results of the study successfully revealed that the formulated sustained release tablet of glipizide could be formulated by use of natural polymers which could provide maximum drug release and this study could further be explored to formulate other doasage forms by using natural source polymers.