Design and Synthesis, In Silico Analysis of Condensed Pyrimidine derivatives as Potent Antimicrobial Agents-Reference-Cited by-同舟云学术

Design and Synthesis, In Silico Analysis of Condensed Pyrimidine derivatives as Potent Antimicrobial Agents

Published:2022-06-28 Issue: Volume: Page:2422-2426
ISSN:0974-360X
Container-title:Research Journal of Pharmacy and Technology
language:en
Short-container-title:RJPT

Author:

Khedkar S. A.¹,Patil J. S.²,Sabale P. M.³

Affiliation:

1. Department of Pharmaceutical Chemistry, JNT University, Kakinada, Andhra Pradesh, India.

2. Shivajirao Jondhale College of Pharmacy, Asangaon, Maharashtra, India.

3. Rashtrasant Tukadoji Maharaj University, Nagpur, Maharashtra, India.

Abstract

A series of 24 condensed pyrimidine derivatives was synthesized via multistep reactions using microwave radiation and have opted to explore the possible inhibition mechanism via virtual analysis by using V life MDS. The synthesized compounds were characterized by spectroscopic analysis. All the synthesized compounds were found to show good in-silico binding analysis which indicated their potential to explore as good antimicrobial agents. All the synthesized derivatives were screened in-vitro for their antibacterial activity against two gram positive and gram negative bacteria. Among the compounds tested, SAKB2, SAKB7, SAKB8, SAKB9 SAKB10, SAKB11, SAKB12 and SAKB13derivatives exhibited potent antimicrobial activity.

Publisher

A and V Publications

Subject

Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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