Affiliation:
1. Department of Chemistry, Kanya Gurukul Campus, Gurukul Kangri Vishwavidyalaya, Haridwar-249404, Uttrakhand, India.
Abstract
Background: This study aimed to examine the anti-inflammatory and antidiabetic effects of the green solvent extract from F.subincisa Buch-Ham.ExSm.This paper also explains how bio-based products have been highly safe and alternative to the use of organic solvent. Methods: The serial extraction was carried out with increasing polarity using a magnetic stirrer: d-limonene, Isopropyl alcohol, Ethyl lactate, and Hydroalcohol.The concentrated and dried extracts were subjected to analysis the antidiabetic activity and anti-inflammatory activity were assessed by employing standard in vitro techniques. Result: In vitro anti-inflammatory assays were performed using heat-induced bovine serum albumin (BSA) denaturation and erythrocyte membrane stabilization assays.α-amylase and α-glucosidase were used to evaluate the anti-diabetic activity of F.subincisa bark in vitro. Diclofenac sodium, Acarbose, and aspirin were used as reference drugs. The in vitro method showed significant anti-inflammatory and anti-diabetic properties of different bio-based extracts tested. Conclusions: Findings from this study showed that F.subincisa exhibited substantial anti-inflammatory and antidiabetic actions in vitro models.
Subject
Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Reference34 articles.
1. Chemat F, Vian MA, Ravi HK, Khadhraoui B, Hilali S, Perino S, et al. Review of Alternative Solvents for Green Extraction of Food and Natural Products : Panorama , Principles ,. 2019;
2. Dick FD. Solvent neurotoxicity. Occup Environ Med. 2006;63(3):221–6.
3. Ullah A. Diabetes mellitus and oxidative stress –– A concise review. Saudi Pharm J [Internet]. 2016;24(5):547–53. Available from: http://dx.doi.org/10.1016/j.jsps.2015.03.013
4. Godavari A, Amutha K. In vitro Antidiabetic Activity of Garcinia mangostana by Enzymatic Inhibition Assay. Res J Pharm Technol. 2017;10(2):508.
5. Amutha K, Aishwarya S. Evaluation of Antibacterial and Antidiabetic Activity and Phytochemical Analysis of Syzygium cumini (l.) Skeels. Seed. Res J Pharmacol Pharmacodyn [Internet]. 2010;2(5):348–50. Available from: http://www.indianjournals.com/ijor.aspx?target=ijor:rjppd&volume=2&issue=5&article=009
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献