Hepatoprotective Activity of Andrographolide and its Semi-Synthetic Derivatives

Abstract

The extensive of liver disease is increase the delight of natural products to treat hepatic diseases. This research aimed to evaluated the hepatoprotective activity of semi-synthetic derivative of andrographolide obtained from Andrographis paniculate (Acanthaceae) generally known as king of bitter. Andrographolide was isolated from the methanolic extract of Andrographis paniculata. In recently various derivative synthesized from andrographolide for pharmacological activity like anti-cancer, antibacterial, anti-diabetic, anti-feedant, anti-viral and so on. In this research 3,19(4-bromo benzylidene) andrographolide were derivatized from andrographolide and evaluate its hepatoprotective potentiality. In this compound 3-19(4-bromo benzylidene andrographolide showed comparatively solubility than andrographolide. In the in- vivo experiment, 3-19(4-bromo benzylidene) andrographolide showed significant hepatoprotective activity by reducing the level of bilirubin, SGOT, SGPT and transminases and histogram support the result. Experimental results showed that 3-19(4-bromo benzylidene derivative able to treat hepatic disease with low toxicity and improved efficacy.