Cytotoxicity Evaluation of Chalcone-Coumarin Conjugates Against A549 Cell Line-Reference-Cited by-同舟云学术

Cytotoxicity Evaluation of Chalcone-Coumarin Conjugates Against A549 Cell Line

Published:2022-11-24 Issue: Volume: Page:5144-5147
ISSN:0974-360X
Container-title:Research Journal of Pharmacy and Technology
language:en
Short-container-title:RJPT

Author:

Prasad Raj Keshwar¹,R. Loksh Kavita¹

Affiliation:

1. Faculty of Pharmacy, Oriental University, Indore, Madhya Pradesh-453555.

Abstract

Coumarins and chalcones have been molecules of considerable interest amongst medicinal chemists owing to their vivid pharmacological potentials including anticancer. A few coumarin-chalcone conjugates (C1-C5) with good antioxidant potential were evaluated for in vitro cytotoxicity against A549 cell lines using MTT assay. The IC50 of the conjugates was calculated after 24 h of treatment. The compounds C3 and C4 with higher mesomeric effects exhibited by the substituents were found to be possessing significant cytotoxic potential with IC50 values of 22.90 ± 2.1, 26.73 ± 6.6 µM respectively.

Publisher

A and V Publications

Subject

Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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