Affiliation:
1. Department of Pharmaceutical Engineering, Faculty of Processes Engineering, Salah Boubnider University-Constantine 3, Constantine 25000, Algeria.
2. National Polytechnic School of Constantine 25000, Algeria.
Abstract
For a better use of the drug, a decrease in side effects, an improvement in effectiveness, and a uniform release of the active ingredients, sustained-release forms have been developed. The objective of this study is to estimate the effect of the factors on the responses involved in the formulation of Diclofenac Sodium (DC) loaded ethylcellulose (EC) microsponges (MP) using Central Composite Design (CCD). Quasi emulsion solvent diffusion method was used to formulate MP. The ratio of ethylcellulose to Diclofenac Sodium and polyvinyl alcohol (PVA) concentration (w/v%) were selected as independent variables for CCD. Entrapment efficiency (EE) and production yield (PY) were selected as dependent variables. The optimal formulation was characterized by Fourier Transform Infrared (FTIR), Optical Microscopy, and in vitro release. Optimized MP showed an EE of 31.02% and a PY of 66.44%, FTIR studies revealed no chemical interaction between drug and polymer used, MP were spherical and present an average size of 9.21±0.3µm. Kinetic studies revealed that drug release from optimized formulation followed Higuchi model. The results demonstrated the effectiveness of proposed design for development of DC microsponges for the sustained release.
Subject
Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献