Formulation and Assessment of Quick dissolving tablet of Candesartan cilexetil arranged from their circular agglomerates

Abstract

Candesartan cilexetil is water insoluble drug which comes under BCS class second category. Drug was used in the treatment of acute and chronic hypertension. The research workgenerally focuses on the solubility enhancement, increasing dissolution behavior, flowability and compressibility of the drug. Tablets and capsule are the solid dosage form mostly used. Spherical agglomerates of Candesartan cilexetil were prepared. Candesartan cilexetil water insoluble drug was used. With the incorporation of polymer, Agglomerates of such drug was prepared. Fast dissolving tablet was prepared and evaluated. Evaluation parameter like FTIR, DSC was carried out. Precompression parameters like bulk density, tap density, angle of repose, compressibility index was carried out. Post compression parameters like friability, hardness, thickness, disintegration time, wetting time was carried out and evaluated. Effect of different disintegrant like Crospovidone, cross carmellose sodium was studied. From in vitro study it was found that cross carmellose sodium containing batch F3 shows better drug release so it shows enhanced dissolution rate while if cross carmellose sodium level increases thus decreasing their dissolution rate.