Antihyperlipidemic Activity of Feronia limonia Leaves Extract against Triton X 100 and High Fat Induced Hyperlipidemic in Rats

Abstract

Objective: The objective of this study was to investigate the antihyperlipidemic activity of Feronia limonia leaves extract in rats. Methods: Hyperlipidemia was induced in rats by feeding high fat diet (HFD) for four successive weeks and Triton X 100(400mg/kg, i.p.) for 24 hours. From 15th to 30th day, extract (250 and 500mg/kg, p.o) and atorvastatin (20mg/kg, p.o.) per se were administered 2 hours prior to feeding rats with high fat diet (HFD). Blood samples of all rats were collected and estimated biochemical parameters on the last day of treatment i.e., 30th day for HFD, and after 24 hours for of Triton X 100 induced hyperlipidaemia using standard diagnostic kits. White adipose tissue obtained from all rats were fixed in 10% formo-saline and analyzed for adipocyte size. Results and Discussion: HFD or Triton X 100 significantly increased serum total cholesterol, triglycerides, LDL-c, and decreased HDL-c concentration. The Extract (250mg/kg, p.o. and 500mg/kg, p.o.) significantly reversed HFD-induced and Triton X 100 induced hyperlipidemia. The adipose tissue of animals which were treated with MEFL showed significant and dose-related decrease in cell size when compared to animals of control group. Conclusions: It can be concluded that extact showed significant anti hyperlipidemic activity in rats and hence it could be a possible herbal medicine for the treatment of hyperlipidemia.