Hepato-Protective effect of Betulinic acid and Rotundic acid on Mercuric Chloride Intoxicated Albino Wistar Rats

Abstract

Mercuric is considered as a highly dangerous, universal environmental toxin and it promotes diverse pathophysiology in many organs appended liver disorders through oxidative stress. Hence, the existing investigation was organized to determine the ameliorative defensive character of betulinic acid and rotundic acid in adult albino male rats hepatotoxicity induced by Mercuric chloride. HgCl2 was given orally for 1.29 mg/kg of body weight of Albino wistar rats for 7 days and betulinic acid and rotundic acid (5mg/kg body weight) was dosed for another 7 days on intoxicated rats. Betulinic acid and rotundic acid treatment significantly improved the defense system through enhancing their enzymatic antioxidant properties [superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)], glutathione (GSH) level and decreased the elevated lipid peroxidation (LPO) content in toxicated rats. Histological alterations of liver tissues induced by HgCl2 were managed by infliction of betulinic acid and rotundic acid. The observed results from the present experiment proposed that betulinic acid and rotundic acid effectively suppress and terminates hepatotoxicity induced through HgCl2 by reliving oxidative stress and liver damage.