Phyllanthus seeds Methanolic extract: In vivo evaluation of Analgesic activity

Abstract

Phyllanthus amarus is a small herb used in tradicinal medicine worldwide. The phytoconstituents of seeds of this plant is evaluated for various medicinal properties.This study was done to evaluate analgesic activity of Phyllanthus amarus seeds in albino mice.Analgesic activity of methanolic extract of Phyllanthus seeds was evaluated using hot plate and Tail clip animal models. Normal saline was used as control drug and standard drug was Morphine and 50 mg,100 and 200 mg/kg of methanolic extract of Phyllanthus seeds was used as test drugs. Phyllanthus seed extract showed statistically significant (p<0.05) increase in the reaction time of animals as compared to control at doses of 100mg/kg and 200 mg/kg at 60 min of drug administration in hot plate method and at 30 min and 60 min of drug administration in tail clip method.The results of the present study shows that methanolic extract of seeds of Phyllanthus amarus showed central analgesic activity in both hot plate and tail clip models in albino mice.