Role of Zinc (II) Bio metal in complexation of Aspirin as Anti Stroke Drug

Abstract

Stroke is becoming one of the biggest health hazardous now days. According to the data, it is estimated that it is becoming a third leading cause of death throughout the world. Aspirin, acetil salicylic acid is well known analgesic, anti-inflammatory and antipyretic drug. It also is having anticancer, anti-oxidant and anticonvulsant property. It plays a significant role in reduction of blood clotting as well as anti-stroke drug. But Aspirin has a property to cause ulcer and Zn bio metal is known to possess anti-ulcer as well as anti-inflammatory property. Keeping the importance of Zn(II) bio metal in mind and Zn(II) - Aspirin complex is prepared, its physicochemical and microbial studies have been carried out in solid and aqueous phases. On the basis of polarographic studies amperometric titrations and IR spectral studies the probable formula for the complex has been worked out to be 1:2. The metal ligand interaction has been studied using polarographic method at 27ºC and ionic strength µ = 1.0. A tentative structure has been suggested to the complex. A microbial study on the complex was carried out against various pathogenic bacteria and fungi. The results of studies revealed that the complex is more effective anti-stroke drug as compared to pure Aspirin.