Wound Healing, Anti-pancreatic Cancer, and α-amylase Inhibitory Potentials of the Edible Mushroom, Metacordyceps neogunnii

Author:

ALKolaibe Abdu Ghalib1,Elkhateeb Waill A.2,Elnahas Marwa O.2,M. El-Manawaty3,CY Deng4,Wen Ting-Chi5,Daba Ghoson M.2

Affiliation:

1. Microbiology Department, Faculty of Science, Taiz University, Taiz, Yemen.

2. Chemistry of Natural and Microbial Products Department, Pharmaceutical Industries Researches Division, National Research Centre, El Buhouth St., Dokki, 12311, Giza, Egypt.

3. Drug Bioassay-Cell Culture Laboratory, Pharmacognosy Department, National Research Centre, Dokki, Giza, 12622, Egypt.

4. Guizhou Institute of Biology, Guizhou Academy of Sciences, Guiyang, Guizhou 550009, China.

5. State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China.

Abstract

Metacordyceps neogunnii is an edible mushroom that has been previously known as Cordyceps gunnii. Recently, it has been proven that Metacordyceps neogunnii differs from similar species by having longer asci and wider ascospores and is phylogenetically distinct to related species. Few studies are available to describe bioactivities exerted by Metacordyceps neogunnii extracts which is insufficient to evaluate the potency of this mushroom. Therefore, the current work was conducted to evaluate the in vitro α-Amylase inhibitory ability, wound healing, and anti-human pancreatic cancer activities of Metacordyceps neogunnii 80% methanolic extract. M. neogunnii extract showed no effect on human cancer pancreatic cell line (Paca2). However, the same extract exhibited slight wound healing effect. On the other hand, M. neogunnii extract exhibited good α-amylase inhibitory activity that reached 69.3±0.78%, and IC50 of 32.38±4.0.

Publisher

A and V Publications

Subject

Pharmacology (medical),Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Bioactive potentials of the truffle mushrooms Tirmania nivea, Tirmania pinoyi and Tuber indicum;Egyptian Pharmaceutical Journal;2024-01

2. Potential of Mushrooms Bioactive for the Treatment of Skin Diseases and Disorders;Journal of Food Biochemistry;2023-12-12

3. Medicinal mushroom: What should we know?;International Journal of Pharmaceutical Chemistry and Analysis;2022-04-15

4. Mushrooms as Efficient Enzymatic Machinery;Journal of Biomedical Research & Environmental Sciences;2022-04

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