Peculiarities of karyotype in patients with miscarriage

Abstract

Objective. To study the features of the karyotype in patients with miscarriage. This article is devoted to the role of maternal chromosome polymorphisms and their role in the genesis of miscarriage. Materials and methods. A comparative assessment of the karyotypes in women, whose pregnancy proceeded without complications and ended in the birth of a healthy child (75 persons, group I), and a group of patients with NB (135 persons, group II) was carried out. Group IIa consisted of 68 women with the first pregnancy that ended in spontaneous abortion in the first trimester, group IIb - 67 women with the first and subsequent pregnancy, interrupted in the first trimester. Statistical processing of the obtained material was carried out using the Exel program, and StatTech v.2.1.0. Results. A significantly greater number of patients with normal karyotype was in group I 72 persons (98.1 %). Data on the structure of chromosome polymorphisms showed that in patients of group II, changes in one chromosome are found in 8.8 % (3 people), two chromosomes in 23.5 % (8 persons). Analysis of the data of group II showed significant differences in the subgroups in the frequency of chromosome polymorphisms, in patients of group IIa changes were noted only in one chromosome, and in IIc, every fifth patient had polymorphism of two chromosomes. Conclusion. Despite the fact that genetic breakdowns are uncontrollable factors and it is not possible to directly influence them, the search for possible mechanisms leading to them is promising.