Сolloidal silicon dioxide in complex therapy of chronic opisthorchiasis

Abstract

BACKGROUND: The uniqueness of the natural data of the region of Western Siberia, the peculiarities of the hydrological regime ensure the stable functioning of foci of opisthorchiasis with a morbidity rate exceeding the indicators in Russia by more than 2 times. The long-term, sometimes forced coexistence of the human body and helminths often leads to serious consequences, which affects the general level of health of the population of endemic territories. With opisthorchiasis, allergies develop, functional disorders of organs (liver, kidneys) and systems (immune, cardiovascular, respiratory, endocrine, digestion), as well as disorders of fat, carbohydrate, mineral metabolism and, in general, hormonal background. The diversity and non-specificity of the clinical manifestations of opisthorchiasis expands the relevance of this problem and requires an increase in the effectiveness of care for such patients, which necessitates the use of enterosorbents. AIMS: is to analyze the effectiveness of the use of the enterosorbent silicon dioxide colloidal (Polysorb MP) in complex therapy of chronic opisthorchiasis. MATERIALS AND METHODS: 214 patients with the chronic phase of opisthorchiasis were analyzed (57.5% of women and 42.5% of men aged 18 to 55 years). The diagnosis of opisthorchiasis invasion was confirmed when helminth eggs were found in the feces (in 72.7%), eggs and/or marites of opisthorchiasis in duodenal contents (in 27.3%). All patients received standard therapy, which included three stages: preparatory; specific chemotherapy; rehabilitation. The complex therapy of patients in the observation group at the stage of pathogenetic preparation included the use of colloidal silicon dioxide. Statistical processing was carried out using methods of variational statistics. RESULTS: The use of the drug silicon dioxide colloidal as part of the complex therapy of chronic opisthorchiasis contributes to a faster improvement ― the relief of allergic manifestations (when using silicon dioxide colloidal amounted to 2.41 (from 2 to 3) days and a significantly significant decrease in total cholesterol and atherogenicity index was noted. CONCLUSION: Silicon dioxide colloidal has shown efficacy in the treatment of patients with opisthorchiasis invasion and disorders in lipid metabolism. Patients noted excellent tolerability and absence of side effects. The method of enterosorption can be recommended for the treatment of opisthorchiasis invasion in patients with lipid metabolism disorders.