Approaches to the compilation of a list of pharmaceuticals and their metabolites subject to state regulation-Reference-Cited by-同舟云学术

Approaches to the compilation of a list of pharmaceuticals and their metabolites subject to state regulation

Published:2024-08-05 Issue:2 Volume:6 Page:56-66
ISSN:2713-1602
Container-title:Pharmacy Formulas
language:
Short-container-title:Pharmacy Formulas

Author:

Shpachuk Arkady Yu.¹,Vilisova Maria A.¹,Sklyarova Natalia A.¹

Affiliation:

1. Saint Petersburg State Chemical and Pharmaceutical University

Abstract

The main sources of entry of pharmaceutical drugs and their active metabolites into drinking water are the pharmaceutical products consumed by the population, which are discharged through the sewage system, the effluents from pharmaceutical and medical organizations, as well as the by-products of agriculture, which ultimately form wastewater that passes through insufficiently effective treatment systems. The study is devoted to the development of approaches to the formation of a list of pharmaceutical products and their metabolites subject to state regulation. The importance of strengthening control over the use of such substances and conducting additional assessments of their negative impact on the environment is emphasized. In the course of the work, a comparative analysis of the active components in the top 20 best-selling pharmaceutical products on the Russian market was carried out using Russian and international literature sources. Regulatory legal acts regulating the classification of antibiotics and hormones by the degree of danger have been studied. Based on this, a preliminary list of medicinal substances that can potentially have a negative impact on the environment has been formed, mainly in accordance with the requirements of SanPiN 1.2.3685-21. The results of the study can be used for further assessments of the harmful effects of these substances and the development of measures for their regulation.

Publisher

ECO-Vector LLC

Link

https://journals.eco-vector.com/PharmForm/article/viewFile/633714/pdf_1

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