Author:
Patyutko Yu. I,Mamontov K. G,Kotelnikov A. G,Ponomarenko A. A,Lazarev A. F
Abstract
Objective: to study influence of preoperative chemotherapy on postoperative complications rate. Material and methods: an analysis of 455 cases of extensive liver resection. 229 (56%) patients didn’t receive neoadjuvant chemotherapy, 176 (44%) - received preoperative chemotherapy. 216 (53%) patients had bilobar lesions, 156 (39%) - had multiple metastases, 168 (42%) - had synchronous metastases, 237 (58%) - had metachronous metastases. 60 (15%) patients in addition to liver lesions, had been resected for extrahepatic metastases. Results: bevacizumab inckusion to preoperative regional chemotherapy did not lead to increase of postoperative complication rate. Conclusion: Postoperative complication rate didn’t significantly differ in all groups of treatment, regardless of liver resection volume. Extension of liver resection from standard hepatectomy to extensive, leads to statistically significant increase of acute hepatic failure. Acute hepatic failure takes the first place among complications (21%).