Acute respiratory syndrome-2 (SARS-CoV-2): A solution of hydrogen peroxide and sodium bicarbonate as an expectorant for recanalization of the respiratory tract and blood oxygenation in respiratory obstruction (review)

Abstract

The immediate cause of death of patients in the final stage of a new coronavirus infection is hypoxia, which develops due to respiratory obstruction. In accordance with the standard of treatment of patients with the most severe atypical pneumonia with COVID-19, artificial lung ventilation and extrapulmonary blood oxygenation are used to preserve their lives. However, these methods do not eliminate airway obstruction, one of the causes of which is mucus hypersecretion. The review shows that a new vector for the search and development of medicines for the drug elimination of hypoxia in respiratory obstruction has been identified in Russia. The high prospects of solutions of hydrogen peroxide and sodium bicarbonate with original physicochemical properties and local mechanisms of action providing urgent recanalization of the respiratory tract and oxygenation of blood in respiratory obstruction caused by blockage of the respiratory tract with thick sputum, mucus, pus and blood are shown. Domestic inventions are indicated, the essence of which is the basis of this scientific direction. Original formulations of solutions of hydrogen peroxide and sodium bicarbonate are given, as well as new technologies for their local application, providing urgent dissolution of mucus, sputum, pus and blood with simultaneous immediate release of oxygen gas.