Representativity of macular edema mapping using en face optical coherence tomography, retinal thickness map, and fluorescein angiography

Abstract

Aim.To study the representativity of macular edema mapping using en face optical coherence tomography (OCT), retinal thickness map, and fluorescein angiography (FA). Methods.In this retrospective cross-sectional study, 8 patients (15 eyes) with diabetic macular edema (2 females and 6 males, mean age 66.58.1 years) were included. All patients OCT (retinal thickness map and en face OCT) and FA were performed. En face slab was constructed between inner plexiform layer and retinal pigment epithelium. Thearea of macular edema was measured by two masked graders independently. Results.There was no statistically significant difference in the area of macular edema between FA, en face OCT, and retinal thickness maps, 12.78.1, 14.58.4, 10.46.9 mm2, respectively (ANOVA3,p=0.34). Intraclass correlation coefficient for three methods was 0.87 and 0.95, for individual and mean values, respectively. Conclusion.En face OCT is an adequate non-invasive alternative for FA in evaluating the area of macular edema and planning of grid macular laser photocoagulation.