Experimental models of type 1 diabetes

Abstract

This article describes currently used experimental animal models of type 1 diabetes. The literature data on the pathogenesis of clinical and morphological patterns of the disease and the possibility of extrapolation have been summarized in the review. In addition, the advantages and disadvantages of each of the models have been evaluated. Based on the reported results, it can be concluded that preclinical research is essential as fundamental basis for the investigation of type 1 diabetes mellitus.