EFFECTIVENESS OF DOMESTIC ANTIRETROVIRAL NRTI CLASS DRUG IN THE MONOTHERAPY OF HIV INFECTION

Abstract

The effectiveness of domestic preparation Phosphazide was proved during the performance of the retrospective analysis of a clinical case of monotherapy in a 28-year-old female with HIV infection. Phosphazide was prescribed after the achievement of virological and immunological effect of combined schedules of antiretroviral therapy. The dynamics of CD4 lymphocytes, plasma HIV RNA [viral load test (VL)] were followed up every 3 months for 372 weeks. The persistent decline in VL and keeping it at the level less than 3,79 log10 in combination with a positive clinical effect - the lack both of symptoms of progression of HIV infection and the development of opportunistic infections, stable level of CD4-lymphocytes> 500 cells/mcl can be considered as a positive result of monotherapy with Phosphazide.