Regenerative medicine and orthobiological drugs possibilities in upper limb diseases treatment: Literature review

Abstract

The analyses of regenerative medicine progress, stem cell biology, and platelet rich plasma growth factor mechanisms of action have pushed many researchers to use orthobiological drugs in their clinical practice. This review aimed to present the use of regenerative techniques and orthobiological drugs in the treatment of upper limb diseases. The open electronic database of PubMed (MEDLINE) was used in the search for scientific studies. The literature search was conducted using the keywords regenerative medicine, orthobiology, hand, wrist joint, platelet rich plasma, mesenchymal stem cells, and stromal-vascular function. The article presents the results and rationale of the use of orthobiological drugs in the treatment of various hand and upper limb pathologies. The use of orthobiological drugs and regenerative techniques in the treatment of upper limb diseases is a safe and promising direction. For the subsequent use of effective cell products, further research is needed to assess their long-term results and development of unified protocols for their use.