Laboratory monitoring of indices in burnt during infection COVID-19

Abstract

The results of laboratory and instrumental studies are analyzed in 46 victims with skin burns of various localization, area and depth of the lesion infected with COVID virus 19 hospitalized in the burn center of Saint-Petersburg Research Institute of Ambulance named after I.I. Dzhanelidze in 2020. The control group included 46 patients with similar severity lesions who were treated at the center in 2018. The data on the general condition of patients, clinical and biochemical blood tests, coagulogram, gas composition, general urine analysis, and X-ray data were assessed. It was found that in the groups of lightly and severely burned and patients in 75.9 and 64.9% of cases, respectively, X-ray examination and computed tomography of the chest organs did not reveal infiltrative changes in the lungs, despite the positive results of virological studies. In the second half of the incubation period, in comparison with the data obtained in the control group, deviations in the following indicators were stated: hemoglobin, hematocrit, leukocytes, neutrophils, lymphocytes, immature granulocytes, erythrocyte sedimentation rate, levels of total protein, creatinine and blood fibrinogen from 1.6% up to 18 times. In other analyzed parameters, no changes were noted. When comparing the data obtained in the second half of the incubation period with the results of laboratory studies of uninfected patients in the group of severely burned patients, significant differences were established among the thrombocyte readings (39.2% less), platelet count (42.9% less), and in the group of lightly burned the number of erythrocytes (less by 11.8%), hemoglobin (less by 19.4%), hematocrit (less by 16.2%) and eosinophils (less by 71%), total protein (less by 5.6%) and creatinine (less by 12.2%). Providing medical care to patients during the pandemic caused by the new coronavirus infection COVID-19 is a challenge for the healthcare system. The results obtained are the first step towards understanding the features of the course of typical pathological processes caused by burn injury and the new coronavirus infection COVID-19.